Here are links to and brief comments about the most important research findings I've posted about on the Blood Sugar 101 FaceBook page over the past six week. I've put the most important in red.
"for women...moderately elevated cholesterol (by current standards) may prove to be not only harmless but even beneficial."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303886/
(Thanks to Peter at the blog, Hyperlipid, for the citation.) This epidemiological study debunks the relationship of Total Cholesterol to cardiovascular death.
*****
Dr. Hattersley (the MODY expert)'s team identifies another gene associated with "Type 2" diabetes in normal weight people.
http://www.sciencedaily.com/releases/2012/06/120601103808.htm
*****
Low dose aspirin raises risk of severe stomach or brain bleeds especially in people with diabetes--cutting heart attacks at the expense of causing strokes and hospitalizations for gastric bleeding (which can be very serious.) A huge epidemiological study should make us rethink the recommendation of daily aspirin.
Research examines major bleeding risk with low-dose aspirin use in patients with and without diabetes
http://www.sciencedaily.com/releases/2012/06/120605172017.htm
*****
A new C-peptide lab test is ACCURATE (unlike the one you had) and can detect very small amounts of insulin production even in people
with longstanding Type 1. Worth reading in full.
http://blog.sstrumello.com/2012/06/new-c-peptide-assay-could-expand.html
*****
Study suggests physicians have no clue as to how to dose post-meal insulin for Type 2s. Shameful.
Patients requiring more than one dose of prandial insulin problematic for physicians
http://www.healio.com/endocrinology/news/online/%7B561B9C43-F901-4497-A57A-684BC9F530E6%7D/Patients-requiring-more-than-one-dose-of-prandial-insulin-problematic-for-physicians
****
Duh. Basal insulin alone is is far more effective than expensive, dangerous oral drugs that may promote cancer. Why does the doctor who comments on this sound so surprised?
http://www.healio.com/endocrinology/news/online/%7B98FB0916-9882-4F51-A2E8-7D9CD2B01C72%7D/Insulin-glargine-bested-sitagliptin-for-HbA1c-reduction-in-insulin-nave-type-2-diabetes
*****
Fish oil (omega-3) fails to affect heart disease or deaths in 12K subject, 6+ year study.
N–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia — NEJM
http://www.nejm.org/doi/full/10.1056/NEJMoa1203859
*****
Whoops, fish oil fails to demonstrate brain-protecting effect in random controlled trials. The way doctors continue to insist it must be good for you reminds me of the response to the low fat diet research that showed the diet did not help prevent heart disease.
http://www.bbc.co.uk/news/health-18410324
*****
Byetta produced A1cs in the 5% range for 1/3 of those who took it in this trial, duplicating what we've seen elsewhere, along with weight loss. Don't let your doctor put you on Victoza instead of Byetta. Byetta is a safer, better tested and more effective drug in the same price range.
Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with diabetes.
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60479-6/abstract
*****
A lower carb, med-adjusted diabetes diet causes modest but maintainable weight loss and blood sugar improvement over 4 years.
http://www.sciencedaily.com/releases/2012/06/120612192756.htm
*****
You need to eat fat with your salad to properly digest the micro nutrients.
Study: No-fat, low-fat dressings don't get most nutrients out of salads
http://www.sciencedaily.com/releases/2012/06/120619230234.htm
*****
1 in 500 obese patients in the open [WLS] surgery group died during or shortly after the procedure, compared to one in 1,000 in the laparoscopic group. But doctors who recommend WLS tell patients to avoid tight blood sugar control as it is "dangerous." Please show me where 1 in 1,000 patients die from tight control!
http://www.reuters.com/article/2012/06/20/us-lessinvasive-weightloss-surgery-idUSBRE85J19920120620
*****
A frightening look at what heartless people whose only interest is their own profits recommend. Raise the A1c for older people to 8% and you eliminate lots of Medicare recipients. And don't forget to enrich surgeons while killing 1 out of 200 people who have WLS. Criminal!
Wall Street Journal: New Strategies for Treating Diabetes
http://online.wsj.com/article_email/SB10001424052702303292204577517041076204350-lMyQjAxMTAyMDAwOTEwNDkyWj.html?mod=wsj_valetleft_email
*****
A good example of the isomer problem I discuss in Diet 101. The lab-created isomer kills people and is the one found in supplements, rather than the expensive natural one.
http://www.sciencedaily.com/releases/2012/07/120712131721.htm
****
Dramatic illustration of difference between visceral (unhealthy) and subcutaneous (cosmetically unappealing) fat. CT scans.
How fat is fat? : The Lancet
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(11)61925-9/fulltext
*****
Phthalates are plasticizers and in most soft bottles and much packaging. Research suggests they are a cause of diabetes.
Diabetes could be linked to phthalates, chemical in common household products, study suggests
http://www.boston.com/dailydose/2012/07/13/diabetes-could-linked-phthalates-chemical-common-household-products-study-suggests/2maQ1UQWxz1pZoKqAOmBFO/story.html
July 16, 2012
June 13, 2012
Jimmy Moore interviews Jenny Ruhl yet again in this new podcast
That sweet-talking Jimmy Moore worked his usual interview magic in yet another podcast which just went live on his site. If you have comments or questions feel free to post them in the comment section of this post.
http://livinlavidalowcarb.com/blog/the-llvlc-show-episode-582-jenny-ruhl-gets-real-sharing-the-truth-about-low-carb-diets/14390
http://livinlavidalowcarb.com/blog/the-llvlc-show-episode-582-jenny-ruhl-gets-real-sharing-the-truth-about-low-carb-diets/14390
June 2, 2012
Interesting Research (FaceBook Links posted since 5/14)
"for women...moderately elevated cholesterol (by current standards) may prove to be not only harmless but even beneficial."
(Thanks to Peter at the blog, Hyperlipid, for the citation.) This huge, long epidemiological study debunks the relationship of Total Cholesterol to cardiovascular death.
THIS IS IMPORTANT. Read the study and look at the charts. (Note: Total cholesterol of 5 mmol/L is 193 mg/dl, 7 mmol is 271 mg/dl.)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303886/
-----
A study confirms that low carb diets are safe for the kidneys. (Not the first, but a fairly large one.)
http://www.foxnews.com/health/2012/06/01/are-low-carb-diets-safe-for-kidneys/
Good news. The CVD death rate among people with diabetes declined by 40% (95% CI 23–54) and all-cause mortality declined by 23% over the past decade.
Trends in Death Rates Among U.S. Adults With and Without Diabetes Between 1997 and 2006
http://care.diabetesjournals.org/content/35/6/1252.full
OBJECTIVE To determine whether all-cause and cardiovascular disease (CVD) death rates declined
-----
Carotid intima-media thickness does not reliably correlate with heart disease risk--though drugs are being sold based on studies that assume it does.
Carotid intima-media thickness progression to predict cardiovascular events in the general population
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60441-3/abstract
-----
In case you don't have enough reasons already not to take Actos. Like brittle bones, macular edema (leading to blindness) and causing heart failure.
http://www.medicalnewstoday.com/articles/246065.php
-----
This may give hope for some people with advanced diabetic neuropathy whose wounds don't heal. The underlying cause is damage to the nerves supplying extremities which are essential for triggering the release of the various immune system com...See More
Discovery Promises Unique Medicine for Treatment of Chronic and Diabetic Wounds
http://www.sciencedaily.com/releases/2012/05/120528100242.htm
-----
This backs up what some smaller studies I've seen have found. Exercise works well for some, for others it has no effect, and for some it makes health worse.
Can Exercise Be Bad for You?
For Some Exercise May Increase Heart Risk
http://well.blogs.nytimes.com/2012/05/30/can-exercise-be-bad-for-you/
-----
People diagnosed with Type 2 under 30 may have MODY. "Only 47% of MODY case subjects identified met current guidelines for diagnostic sequencing." Especially likely if diagnosed under 30 or under 45 without "metabolic syndrome."
Systematic Assessment of Etiology in Adults With a Clinical Diagnosis of Young-Onset Type 2 Diabetes
http://care.diabetesjournals.org/content/35/6/1206.abstract
-----
Diet causes growth of neurons in the hypothalamus leading to weight gain. I wonder if SSRIs also cause this overgrowth in they hypothalamus. They do in the hippocampus. (Note this is a mouse study, but it has very interesting implications.)
Weight struggles? Blame new neurons in your hypothalamus
http://www.sciencedaily.com/releases/2012/05/120521115331.htm
-----
Not really diabetes news but absolutely amazing. Use of sound gives people born blind ability to read eye charts.
Training the blind to 'see' using new device to 'listen' to visual informatoin
http://www.sciencedaily.com/releases/2012/05/120516093156.htm
-----
Fake industry-supported lobbying groups ensure your right to be exposed to endocrine disrupters linked with diabetes and worse.
Are You Safe on That Sofa?
http://www.nytimes.com/2012/05/20/opinion/sunday/kristof-are-you-safe-on-that-sofa.html
-----
Yet another study showing that cutting carbs lowers blood sugar that will be ignored by the ADA.
Swedes Lob Dynamite Into a Controversy: High-Fat Diet Improves Blood Sugars - Diabetes Health
http://www.diabeteshealth.com/read/2012/05/20/7533/swedes-lob-dynamite-into-a-controversy-high-fat-diet-improves-blood-sugars/
-----
It's only 7 years since I posted the documentation supporting the idea that prediabetic blood sugars cause neuropathy. Now the Lancet acts like this is news.
http://www.healio.com/endocrinology/news/online/%7BFEC3820C-6604-4589-B8A7-600E7938AFD9%7D/Prediabetes-other-metabolic-syndromes-could-be-linked-to-neuropathy
-----
"Sulfonamides, macrolides and other antibiotic traces have been found [in baby food], as well as anthelmintics (anti-worm) and fungicides." Another subtle factor damaging our genes?
New method detects traces of veterinary drugs in baby food
http://www.sciencedaily.com/releases/2012/05/120518132416.htm
(Thanks to Peter at the blog, Hyperlipid, for the citation.) This huge, long epidemiological study debunks the relationship of Total Cholesterol to cardiovascular death.
THIS IS IMPORTANT. Read the study and look at the charts. (Note: Total cholesterol of 5 mmol/L is 193 mg/dl, 7 mmol is 271 mg/dl.)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303886/
-----
A study confirms that low carb diets are safe for the kidneys. (Not the first, but a fairly large one.)
http://www.foxnews.com/health/2012/06/01/are-low-carb-diets-safe-for-kidneys/
Good news. The CVD death rate among people with diabetes declined by 40% (95% CI 23–54) and all-cause mortality declined by 23% over the past decade.
Trends in Death Rates Among U.S. Adults With and Without Diabetes Between 1997 and 2006
http://care.diabetesjournals.org/content/35/6/1252.full
OBJECTIVE To determine whether all-cause and cardiovascular disease (CVD) death rates declined
-----
Carotid intima-media thickness does not reliably correlate with heart disease risk--though drugs are being sold based on studies that assume it does.
Carotid intima-media thickness progression to predict cardiovascular events in the general population
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60441-3/abstract
-----
In case you don't have enough reasons already not to take Actos. Like brittle bones, macular edema (leading to blindness) and causing heart failure.
http://www.medicalnewstoday.com/articles/246065.php
-----
This may give hope for some people with advanced diabetic neuropathy whose wounds don't heal. The underlying cause is damage to the nerves supplying extremities which are essential for triggering the release of the various immune system com...See More
Discovery Promises Unique Medicine for Treatment of Chronic and Diabetic Wounds
http://www.sciencedaily.com/releases/2012/05/120528100242.htm
-----
This backs up what some smaller studies I've seen have found. Exercise works well for some, for others it has no effect, and for some it makes health worse.
Can Exercise Be Bad for You?
For Some Exercise May Increase Heart Risk
http://well.blogs.nytimes.com/2012/05/30/can-exercise-be-bad-for-you/
-----
People diagnosed with Type 2 under 30 may have MODY. "Only 47% of MODY case subjects identified met current guidelines for diagnostic sequencing." Especially likely if diagnosed under 30 or under 45 without "metabolic syndrome."
Systematic Assessment of Etiology in Adults With a Clinical Diagnosis of Young-Onset Type 2 Diabetes
http://care.diabetesjournals.org/content/35/6/1206.abstract
-----
Diet causes growth of neurons in the hypothalamus leading to weight gain. I wonder if SSRIs also cause this overgrowth in they hypothalamus. They do in the hippocampus. (Note this is a mouse study, but it has very interesting implications.)
Weight struggles? Blame new neurons in your hypothalamus
http://www.sciencedaily.com/releases/2012/05/120521115331.htm
-----
Not really diabetes news but absolutely amazing. Use of sound gives people born blind ability to read eye charts.
Training the blind to 'see' using new device to 'listen' to visual informatoin
http://www.sciencedaily.com/releases/2012/05/120516093156.htm
-----
Fake industry-supported lobbying groups ensure your right to be exposed to endocrine disrupters linked with diabetes and worse.
Are You Safe on That Sofa?
http://www.nytimes.com/2012/05/20/opinion/sunday/kristof-are-you-safe-on-that-sofa.html
-----
Yet another study showing that cutting carbs lowers blood sugar that will be ignored by the ADA.
Swedes Lob Dynamite Into a Controversy: High-Fat Diet Improves Blood Sugars - Diabetes Health
http://www.diabeteshealth.com/read/2012/05/20/7533/swedes-lob-dynamite-into-a-controversy-high-fat-diet-improves-blood-sugars/
-----
It's only 7 years since I posted the documentation supporting the idea that prediabetic blood sugars cause neuropathy. Now the Lancet acts like this is news.
http://www.healio.com/endocrinology/news/online/%7BFEC3820C-6604-4589-B8A7-600E7938AFD9%7D/Prediabetes-other-metabolic-syndromes-could-be-linked-to-neuropathy
-----
"Sulfonamides, macrolides and other antibiotic traces have been found [in baby food], as well as anthelmintics (anti-worm) and fungicides." Another subtle factor damaging our genes?
New method detects traces of veterinary drugs in baby food
http://www.sciencedaily.com/releases/2012/05/120518132416.htm
May 31, 2012
The Problem with FaceBook
As an experiment, I set up a Blood Sugar 101 FaceBook page last year to see if I could spread more awareness of blood-sugar related issues.
The page attracted a lot of interest and currently has over 1,100 "likes." But FaceBook had to do something to justify the billions it winkled out of investors, and what it has done is pernicious. After urging content providers to generate likes--even suggesting that we advertise with FaceBook to raise the number of people who like our page (I didn't), FaceBook has now stopped showing page updates to most people who have liked our pages.
I had noticed this when I reviewed the feeble stats that FaceBook provides for pages. Then I read online that only 20% of people who had liked a page were seeing the updates. A poll I posted as an update on the Blood Sugar 101 FaceBook page a few weeks ago confirmed this. Only 20% of the people who had liked the post responded to a question about whether they could see the feed.
Now when I post on the Blood Sugar 101 FaceBook page, FaceBook is hitting me with something new--a chance to PAY for the ability to have my status updates seen by the people who have already liked the page. (Details here.) For a mere $5-10 bucks per update I can ensure that people who subscribed to my page under the impression that it meant they would see the updates can see those updates.
If this had been explained explicitly when I created the page, that would be one thing. But this was not at all the way that FaceBook worked a year ago when I started the page. For example, FaceBook has also disabled the ability of page owners to contact those who have liked their pages--a feature that was intact when I created my page and was part of what attracted me to doing it.
I don't spam people, but now and then it would be nice to be able to send out messages about particularly important events. Not so coincidentally, FaceBook took away my ability to contact page likers just at the time they started charging for the ability to have those same subscribers see feeds.
This is making me seriously reconsider whether I should post on FaceBook at all. FaceBook is using the fact that people like my page to gather information they sell to marketers who then target those people. Since my page discusses diabetes and diet, people who like the page will get shown ads for the kind of crap exploiters love to push on people with diabetes.
Since Blogger has never played these kinds of games with me I'm liking the blog more and more and am thinking I'll move my posting activity back to the blog. But because many of the people who do still see my feeds have asked me to keep the FaceBook page going, for now I am going to keep the Blood Sugar 101 FaceBook page alive.
However, if you are on FaceBook and interested in seeing the feeds there, don't assume FaceBook will show them to you. To see the updates, you'll have to bookmark the page and remember to visit it from time to time to see the updates.
If you are active on FaceBook, it would be a good idea to also warn your friends that FaceBook is probably not showing them the feeds from pages they want to follow and that they are charging page creators for the "privilege" of having their feeds seen. Though you may find that many of those who have liked your page are no longer seeing your feeds either.
The page attracted a lot of interest and currently has over 1,100 "likes." But FaceBook had to do something to justify the billions it winkled out of investors, and what it has done is pernicious. After urging content providers to generate likes--even suggesting that we advertise with FaceBook to raise the number of people who like our page (I didn't), FaceBook has now stopped showing page updates to most people who have liked our pages.
I had noticed this when I reviewed the feeble stats that FaceBook provides for pages. Then I read online that only 20% of people who had liked a page were seeing the updates. A poll I posted as an update on the Blood Sugar 101 FaceBook page a few weeks ago confirmed this. Only 20% of the people who had liked the post responded to a question about whether they could see the feed.
Now when I post on the Blood Sugar 101 FaceBook page, FaceBook is hitting me with something new--a chance to PAY for the ability to have my status updates seen by the people who have already liked the page. (Details here.) For a mere $5-10 bucks per update I can ensure that people who subscribed to my page under the impression that it meant they would see the updates can see those updates.
If this had been explained explicitly when I created the page, that would be one thing. But this was not at all the way that FaceBook worked a year ago when I started the page. For example, FaceBook has also disabled the ability of page owners to contact those who have liked their pages--a feature that was intact when I created my page and was part of what attracted me to doing it.
I don't spam people, but now and then it would be nice to be able to send out messages about particularly important events. Not so coincidentally, FaceBook took away my ability to contact page likers just at the time they started charging for the ability to have those same subscribers see feeds.
This is making me seriously reconsider whether I should post on FaceBook at all. FaceBook is using the fact that people like my page to gather information they sell to marketers who then target those people. Since my page discusses diabetes and diet, people who like the page will get shown ads for the kind of crap exploiters love to push on people with diabetes.
Since Blogger has never played these kinds of games with me I'm liking the blog more and more and am thinking I'll move my posting activity back to the blog. But because many of the people who do still see my feeds have asked me to keep the FaceBook page going, for now I am going to keep the Blood Sugar 101 FaceBook page alive.
However, if you are on FaceBook and interested in seeing the feeds there, don't assume FaceBook will show them to you. To see the updates, you'll have to bookmark the page and remember to visit it from time to time to see the updates.
If you are active on FaceBook, it would be a good idea to also warn your friends that FaceBook is probably not showing them the feeds from pages they want to follow and that they are charging page creators for the "privilege" of having their feeds seen. Though you may find that many of those who have liked your page are no longer seeing your feeds either.
May 14, 2012
Links to Studies Posted on the FaceBook Blood Sugar 101 Page
Because posts on FB scroll off I'm reposting the posts I've made on the Blood Sugar 101 FaceBook Page so that they will still be available here when they are gone from FB.
THE POSTS:
Scientists may not understand what causes painful neuropathy, but I hear all the time from people who have cured it by dropping bgs below 140 mg/dl at all times.
Scientists uncover potential treatment for painful side effect of diabetes
----
FDA about to approve Lorcaserin which achieves 5% weight loss in less than 50% of obese people over a year. Magic it ain't.
http://www.nejm.org/doi/full/10.1056/NEJMoa0909809
----
If you want to stop smoking and not gain weight, cut your carbs then quit.
Increased bodyweight after stopping smoking may be due to changes in insulin secretion
----
Researchers "take advantage of a new mouse model of diabetes type 2, which, like humans, develops the disease in adults as result of a high-fat diet." Which means it doesn't have the same diabetes humans get which is genetically almost always from insufficient insulin production combined with factors that make for insulin resistance like mitochondria that burn glucose poorly.
Caffeine can prevent memory loss in diabetes
----
Experimental basal #insulin that lasts 40 hours gives almost the same results as Lantus with slightly less nighttime hypos. But blood sugars still remain high because of the way it's dosed.
Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment
----
Phthalates have also been linked with #diabetes in older people. Hard to eliminate our exposure. They're in everything.
Washington Post: If the food’s in plastic, what’s in the food?
----
The news about #metformin just keeps getting better. It seems to protect against Parkinson's too!
Metformin can substantially reduce the risk of Parkinson's disease in diabetes, study suggests
---
Serum levels of phthalate metabolites are linked with the development of type 2 diabetes in the elderly, Swedish researchers found.
Medical News:%20Common Chemical Tied to Diabetes in Seniors - in Endocrinology, Diabetes from MedPage
----
This is about Type 1 #diabetes and mice, but it's still interesting and may have an application for Type 2, also.
Magnetic Nanoparticles Predict Diabetes Onset: Researchers from Harvard Medical School and Massachusetts General Hospital have developed a magnetic nanoparticle-based MRI technique for predicting whether—and when—subjects with a genetic predisposition for diabetes will develop the disease.
http://hms.harvard.edu/content/magnetic-nanoparticles-predict-diabetes-onset
---
Blocking glucagon is way far from being a real treatment for #diabetes but it's an interesting concept.
Targeting glucagon pathway may offer a new approach to treating diabetes
---
Slightly higher than normal blood sugars cause bad pregnancy outcomes, just as they cause #diabetes complications. Will doctors ever challenge the ADA's damagingly high diagnostic criteria?
New pregnancy risk for babies and moms: Overweight moms with moderately high blood sugar raise health risk
----
Humans have evolved unique genes for fat metabolism, which supports our big brain. One reason why rodent research is so misleading.
Genetic adaptation of fat metabolism key to development of human brain
----
Yet another study attributes to weight loss the effect of the mandatory carb-cutting enforced by WLS. The surgeons won't stop until everyone has this surgery. Note, that the incidence of diabetes in the most heaviest subjects in this group was under 10% and dropped by less than 6%. Most obese people will never develop diabetes, despite the hype. You need the genes to get it, and you need to cut carbs to lower your blood sugar. WLS isn't a "cure" it's a way of forcing people to cut carbs involuntarily.
Losing Weight When Obese Can Prevent or Cure Diabetes, Whatever the Initial BMI, Study Suggests
----
Yet another antioxidant vitamin pill turns out to be harmful--Beta Carotene. Eat your veggies, folks and leave the pills on the shelf!
Potential 'dark side' to diets high in beta-carotene
---
Confirmation of what we all know, bananas, oatmeal, and oral drugs won't do it. If only they taught these teens to cut carbs!
TODAY — A Stark Glimpse of Tomorrow — NEJM
also An Editorial on the Same Study.
----
Read this list of unnecessary tests that you should NOT let a cardiologist perform on you. I've had some and refused another despite heavy pressure from an ER doctor. (I'd gone to the ER for something unrelated.) The last one can kill you.
http://choosingwisely.org/wp-content/uploads/2012/04/5things_12_factsheet_Amer_Coll_Cardio.pdf
From the same site's nephrology page: "Avoid nonsteroidal anti-inflammatory drugs (NSAIDS) in individuals with hypertension or heart failure or CKD of all causes, including diabetes.The use of NSAIDS, including cyclo-oxygenase type 2 (COX-2) inhibitors, for the pharmacological treatment of musculoskeletal pain can elevate blood pressure, make antihypertensive drugs less effective, cause fluid retention and worsen kidney function in these individuals. Other agents such as acetaminophen, tramadol or short-term use of narcotic analgesics may be safer than and as effective as NSAIDs."
----
Note that the recommendation is to get this nutrient from food, not pills. Chicken thighs will work. Bake them until crispy, paint with buffalo chicken hot sauce. Yum.Nutrient found in dark meat of poultry, some seafood, may have cardiovascular benefits
A nutrient found in the dark meat of poultry may provide protection against coronary heart disease in women with high cholesterol, according to a new study.
----
Experimental drug stimulates a free fatty acid receptor in the pancreas which causes insulin secretion. And weight gain. What else it does it unknown as the testing on humans was brief and in few subjects.
Medical News:New Diabetes Drug Cuts Glycemic Risk - in Endocrinology, Diabetes from MedPage Today
-----
We recently learned Bisphenol A doubles insulin resistance, so a connection with heart disease is not that mysterious. I wish they'd correlated it with A1c. The EPIC-Norfolk study is the one that first found the tight correlation between A1c and heart disease even in the normal range.
Bisphenol A exposure linked to increased risk of future onset of heart disease
----
Maternal PFOA blood levels => Fat daughters 20 years later. The obesity crisis's NOT just about lifestyle choices poeple.
The levels of the environmental pollutant perfluorooctanoic acid (PFOA) that mothers had in their blood during pregnancy increased the risk of obesity in their daughters at 20 years of age.
----
Another reason to avoid those vegan "health food" diets. Arsenic is linked to rising rates of Type 2 diabetes. Next time you pick up an organic cereal bar or buy infant formula, you might want to read the label closely.
Arsenic found in organic baby food, cereal bars
todayhealth.today.msnbc.msn.co?m
----
Yet another study in which supplementing with Vitamin D does NOT improve a condition associated with low Vitamin D levels but raises blood calcium--which is dangerous to your heart. Go easy on the Vitamin D folks!
Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking.
----
Huge study "Surprisingly, LDL cholesterol and total cholesterol, however, were not associated with stroke risk in this population" (Older women) Triglycerides were.
Lose the carbs, baby! Carbs are what raise triglycerides.
Triglyceride levels predict stroke risk in postmenopausal women
----
Research, mostly rodent, showing raising insulin doesn't cause obesity unless you create hypoglycemia. Don't believe doctors who refuse insulin because "it will make you fat." Dose it right, and it won't. (I lost weight when I started insulin.)
Whole Health Source: Insulin and Obesity: Another Nail in the Coffin
----
MRI scan 'better' for heart patients
A magnetic resonance imaging scan for coronary heart disease is better than the most commonly-used alternative, a major UK trial of heart disease patients has shown.
MRI is better at detecting heart disease, and safer than angiogram since it doesn't involve x-rays.
----
An investigation by the Centers for Disease Control and Prevention, found that between 1996 and 2008, the amount of leg and foot amputations among U.S. individuals, aged 40+ with diagnosed diabetes dropped. This is good news, but there are still too many people getting amputations, mostly the very old and people in under-served poverty-striken communities who can't afford medical treatment that could lower their blood sugars.
Lower Limb Amputation Rates Associated With Diabetes Drop,
----
Thousands of untested new supplements have flooded the market with only the manufacturer's say-so attesting to their safety. Read this article in full if you buy pills you are told are "natural." They may contain dangerous ingredients.
http://www.nejm.org/doi/full/10.1056/NEJMp1113325
THE POSTS:
Scientists may not understand what causes painful neuropathy, but I hear all the time from people who have cured it by dropping bgs below 140 mg/dl at all times.
Scientists uncover potential treatment for painful side effect of diabetes
----
FDA about to approve Lorcaserin which achieves 5% weight loss in less than 50% of obese people over a year. Magic it ain't.
http://www.nejm.org/doi/full/10.1056/NEJMoa0909809
----
If you want to stop smoking and not gain weight, cut your carbs then quit.
Increased bodyweight after stopping smoking may be due to changes in insulin secretion
----
Researchers "take advantage of a new mouse model of diabetes type 2, which, like humans, develops the disease in adults as result of a high-fat diet." Which means it doesn't have the same diabetes humans get which is genetically almost always from insufficient insulin production combined with factors that make for insulin resistance like mitochondria that burn glucose poorly.
Caffeine can prevent memory loss in diabetes
----
Experimental basal #insulin that lasts 40 hours gives almost the same results as Lantus with slightly less nighttime hypos. But blood sugars still remain high because of the way it's dosed.
Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment
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Phthalates have also been linked with #diabetes in older people. Hard to eliminate our exposure. They're in everything.
Washington Post: If the food’s in plastic, what’s in the food?
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The news about #metformin just keeps getting better. It seems to protect against Parkinson's too!
Metformin can substantially reduce the risk of Parkinson's disease in diabetes, study suggests
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Serum levels of phthalate metabolites are linked with the development of type 2 diabetes in the elderly, Swedish researchers found.
Medical News:%20Common Chemical Tied to Diabetes in Seniors - in Endocrinology, Diabetes from MedPage
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This is about Type 1 #diabetes and mice, but it's still interesting and may have an application for Type 2, also.
Magnetic Nanoparticles Predict Diabetes Onset: Researchers from Harvard Medical School and Massachusetts General Hospital have developed a magnetic nanoparticle-based MRI technique for predicting whether—and when—subjects with a genetic predisposition for diabetes will develop the disease.
http://hms.harvard.edu/content/magnetic-nanoparticles-predict-diabetes-onset
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Blocking glucagon is way far from being a real treatment for #diabetes but it's an interesting concept.
Targeting glucagon pathway may offer a new approach to treating diabetes
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Slightly higher than normal blood sugars cause bad pregnancy outcomes, just as they cause #diabetes complications. Will doctors ever challenge the ADA's damagingly high diagnostic criteria?
New pregnancy risk for babies and moms: Overweight moms with moderately high blood sugar raise health risk
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Humans have evolved unique genes for fat metabolism, which supports our big brain. One reason why rodent research is so misleading.
Genetic adaptation of fat metabolism key to development of human brain
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Yet another study attributes to weight loss the effect of the mandatory carb-cutting enforced by WLS. The surgeons won't stop until everyone has this surgery. Note, that the incidence of diabetes in the most heaviest subjects in this group was under 10% and dropped by less than 6%. Most obese people will never develop diabetes, despite the hype. You need the genes to get it, and you need to cut carbs to lower your blood sugar. WLS isn't a "cure" it's a way of forcing people to cut carbs involuntarily.
Losing Weight When Obese Can Prevent or Cure Diabetes, Whatever the Initial BMI, Study Suggests
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Yet another antioxidant vitamin pill turns out to be harmful--Beta Carotene. Eat your veggies, folks and leave the pills on the shelf!
Potential 'dark side' to diets high in beta-carotene
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Confirmation of what we all know, bananas, oatmeal, and oral drugs won't do it. If only they taught these teens to cut carbs!
TODAY — A Stark Glimpse of Tomorrow — NEJM
also An Editorial on the Same Study.
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Read this list of unnecessary tests that you should NOT let a cardiologist perform on you. I've had some and refused another despite heavy pressure from an ER doctor. (I'd gone to the ER for something unrelated.) The last one can kill you.
http://choosingwisely.org/wp-content/uploads/2012/04/5things_12_factsheet_Amer_Coll_Cardio.pdf
From the same site's nephrology page: "Avoid nonsteroidal anti-inflammatory drugs (NSAIDS) in individuals with hypertension or heart failure or CKD of all causes, including diabetes.The use of NSAIDS, including cyclo-oxygenase type 2 (COX-2) inhibitors, for the pharmacological treatment of musculoskeletal pain can elevate blood pressure, make antihypertensive drugs less effective, cause fluid retention and worsen kidney function in these individuals. Other agents such as acetaminophen, tramadol or short-term use of narcotic analgesics may be safer than and as effective as NSAIDs."
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Note that the recommendation is to get this nutrient from food, not pills. Chicken thighs will work. Bake them until crispy, paint with buffalo chicken hot sauce. Yum.Nutrient found in dark meat of poultry, some seafood, may have cardiovascular benefits
A nutrient found in the dark meat of poultry may provide protection against coronary heart disease in women with high cholesterol, according to a new study.
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Experimental drug stimulates a free fatty acid receptor in the pancreas which causes insulin secretion. And weight gain. What else it does it unknown as the testing on humans was brief and in few subjects.
Medical News:New Diabetes Drug Cuts Glycemic Risk - in Endocrinology, Diabetes from MedPage Today
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We recently learned Bisphenol A doubles insulin resistance, so a connection with heart disease is not that mysterious. I wish they'd correlated it with A1c. The EPIC-Norfolk study is the one that first found the tight correlation between A1c and heart disease even in the normal range.
Bisphenol A exposure linked to increased risk of future onset of heart disease
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Maternal PFOA blood levels => Fat daughters 20 years later. The obesity crisis's NOT just about lifestyle choices poeple.
The levels of the environmental pollutant perfluorooctanoic acid (PFOA) that mothers had in their blood during pregnancy increased the risk of obesity in their daughters at 20 years of age.
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Another reason to avoid those vegan "health food" diets. Arsenic is linked to rising rates of Type 2 diabetes. Next time you pick up an organic cereal bar or buy infant formula, you might want to read the label closely.
Arsenic found in organic baby food, cereal bars
todayhealth.today.msnbc.msn.co?m
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Yet another study in which supplementing with Vitamin D does NOT improve a condition associated with low Vitamin D levels but raises blood calcium--which is dangerous to your heart. Go easy on the Vitamin D folks!
Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking.
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Huge study "Surprisingly, LDL cholesterol and total cholesterol, however, were not associated with stroke risk in this population" (Older women) Triglycerides were.
Lose the carbs, baby! Carbs are what raise triglycerides.
Triglyceride levels predict stroke risk in postmenopausal women
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Research, mostly rodent, showing raising insulin doesn't cause obesity unless you create hypoglycemia. Don't believe doctors who refuse insulin because "it will make you fat." Dose it right, and it won't. (I lost weight when I started insulin.)
Whole Health Source: Insulin and Obesity: Another Nail in the Coffin
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MRI scan 'better' for heart patients
A magnetic resonance imaging scan for coronary heart disease is better than the most commonly-used alternative, a major UK trial of heart disease patients has shown.
MRI is better at detecting heart disease, and safer than angiogram since it doesn't involve x-rays.
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An investigation by the Centers for Disease Control and Prevention, found that between 1996 and 2008, the amount of leg and foot amputations among U.S. individuals, aged 40+ with diagnosed diabetes dropped. This is good news, but there are still too many people getting amputations, mostly the very old and people in under-served poverty-striken communities who can't afford medical treatment that could lower their blood sugars.
Lower Limb Amputation Rates Associated With Diabetes Drop,
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Thousands of untested new supplements have flooded the market with only the manufacturer's say-so attesting to their safety. Read this article in full if you buy pills you are told are "natural." They may contain dangerous ingredients.
http://www.nejm.org/doi/full/10.1056/NEJMp1113325
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