However, it is likely this is because Avandia and Actos CAUSE heart failure, rather than that these other drugs prevent it. People are rarely put on both families of drugs at once.
It may also be because these GLP-1 related drugs are mostly prescribed to affluent, younger people with diabetes and good health insurance, while poorer people are put on the cheap sulfonylurea drugs which are now known to raise the risk of heart attacks.
Paleo fans will probably ignore the news that Mummy CT Scans Show Preindustrial Hunter Gatherers Had Clogged Arteries. From the report "The researchers performed CT scans of 137 mummies from across four continents and found artery plaque in every single population studied, from preagricultual hunter-gatherers in the Aleutian Islands to the ancient Puebloans of southwestern United States."
So plaque probably is some byproduct of an adaptation in the way humans process calcium--probably one that is a byproduct of the genetic changes that led to our species' distinctive bigger brains and smaller digestive tracts.
The Paleo diet is useful in helping cut back on junk food, but the idea that ancient humans were healthier than we are is almost certainly a fantasy. The life expectancies of junk food chomping modern day humans is far longer than that of any pre-agricultural peoples, if only because we have effective treatment for injuries and contagious diseases.
I remember playing outside in the summer in 1954, and the spray truck passing by spraying huge clouds of DDT. We would take deep breaths of the stuff which had a curious smell. Later, before we went to sleep, my mom would spray my bedroom with it and then I'd crawl right into bed.
More problems with all incretin drugs--Byetta, Januvia, Onglyza, Victoza, etc. How many people will suffer life changing complications before the FDA acts? I bet your doctor is completely unaware of this ratcheting up of concern.
A bakery is found to have put sugar in its sugar-free baked goods. The really sad part is that no one seems to understand that the FLOUR in the baked goods is digested into glucose every bit as toxic to people with diabetes as the sucrose. (See last line for what I mean.)
This is to Skippy Pea, I deleted your comment because you had what looks like a ununintended Autocorrect" issue, but the answer to your question is that I don't recommend any protein meal replacements. I don't think they help with dieting and the ingredients are usually cheap omega 6 oils, chemical additives, and poor quality proteins. Why not try some Greek Yogurt with nuts and perhaps some berries instead?
Victoza (Liraglutide) does not provide significant weight loss in a new study. This reinforces my belief that it isn't as effective a drug as Byetta, while causing much more troubling side effects.
It produced only 4% more weight loss than a worthless placebo. That's 8 lbs lost more than on placebo for someone weighing 200 lbs--which you can easily accomplish without drugs by eating a very low carb diet for a month.
Note that this was on a high dose regimen, and that this drug has been connected with both thyroid cancer and pancreatitis at normal doses.
Some new research supports the "hygiene hypothesis" that Type 1 Diabetes is becoming epidemic because kids are growing up too clean and not encountering bacteria etc at critical stages of the development of the immune system.
Practical takeaway: let your kids play outside in real dirt when they are young and don't use antibiotic soaps.
Interesting but very small study about the impact of supplementing with Vitamin D on various genes. Note that quite a few much larger studies have found ZERO impact of such supplementation on Type 1 diabetes, MS, or any other already existing autoimmune condition. If there is a benefit in supplementing with Vitamin D it occurs only before you have developed an autoimmunity.
Also note that they did measure blood levels after the supplementation which ended up on average in the low end of the normal range at 32 ng/ml. They did not observe what happens if you oversupplement and reach the much higher levels where nasty things can start happening to your calcium metabolism.
Visit the mainBlood Sugar 101 Web Site to learn more about how blood sugar works, what blood sugar levels cause organ damage, what blood sugar levels are safe and how to achieve those safe blood sugar levels.
I was diagnosed with diabetes in 1998. Since then I've kept my A1cs in the 5.0-6.0% range using the techniques you'll find explained at The main Blood Sugar 101 Web Site, where you'll also find extensive discussion of the peer-reviewed research that backs up the statements you read here.
I've also published two books on related subjects, Blood Sugar 101: What They Don't Tell You About Diabetes, which was an Amazon Diabetes bestseller for 3 years and my latest book, Diet 101: The Truth About Low Carb Diets.