May 14, 2012

Links to Studies Posted on the FaceBook Blood Sugar 101 Page

Because posts on FB scroll off I'm reposting the posts I've made on the Blood Sugar 101 FaceBook Page so that they will still be available here when they are gone from FB.


Scientists may not understand what causes painful neuropathy, but I hear all the time from people who have cured it by dropping bgs below 140 mg/dl at all times.

Scientists uncover potential treatment for painful side effect of diabetes


FDA about to approve Lorcaserin which achieves 5% weight loss in less than 50% of obese people over a year. Magic it ain't.


If you want to stop smoking and not gain weight, cut your carbs then quit.

Increased bodyweight after stopping smoking may be due to changes in insulin secretion

Researchers "take advantage of a new mouse model of diabetes type 2, which, like humans, develops the disease in adults as result of a high-fat diet." Which means it doesn't have the same diabetes humans get which is genetically almost always from insufficient insulin production combined with factors that make for insulin resistance like mitochondria that burn glucose poorly.

Caffeine can prevent memory loss in diabetes

Experimental basal #insulin that lasts 40 hours gives almost the same results as Lantus with slightly less nighttime hypos. But blood sugars still remain high because of the way it's dosed.

Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment

Phthalates have also been linked with #diabetes in older people. Hard to eliminate our exposure. They're in everything.
Washington Post: If the food’s in plastic, what’s in the food?


The news about #metformin just keeps getting better. It seems to protect against Parkinson's too!

Metformin can substantially reduce the risk of Parkinson's disease in diabetes, study suggests


Serum levels of phthalate metabolites are linked with the development of type 2 diabetes in the elderly, Swedish researchers found.

Medical News:%20Common Chemical Tied to Diabetes in Seniors - in Endocrinology, Diabetes from MedPage


This is about Type 1 #diabetes and mice, but it's still interesting and may have an application for Type 2, also.

Magnetic Nanoparticles Predict Diabetes Onset: Researchers from Harvard Medical School and Massachusetts General Hospital have developed a magnetic nanoparticle-based MRI technique for predicting whether—and when—subjects with a genetic predisposition for diabetes will develop the disease.


Blocking glucagon is way far from being a real treatment for #diabetes but it's an interesting concept.

Targeting glucagon pathway may offer a new approach to treating diabetes

Slightly higher than normal blood sugars cause bad pregnancy outcomes, just as they cause #diabetes complications. Will doctors ever challenge the ADA's damagingly high diagnostic criteria?

New pregnancy risk for babies and moms: Overweight moms with moderately high blood sugar raise health risk

Humans have evolved unique genes for fat metabolism, which supports our big brain. One reason why rodent research is so misleading.

Genetic adaptation of fat metabolism key to development of human brain


Yet another study attributes to weight loss the effect of the mandatory carb-cutting enforced by WLS. The surgeons won't stop until everyone has this surgery. Note, that the incidence of diabetes in the most heaviest subjects in this group was under 10% and dropped by less than 6%. Most obese people will never develop diabetes, despite the hype. You need the genes to get it, and you need to cut carbs to lower your blood sugar. WLS isn't a "cure" it's a way of forcing people to cut carbs involuntarily.

Losing Weight When Obese Can Prevent or Cure Diabetes, Whatever the Initial BMI, Study Suggests


Yet another antioxidant vitamin pill turns out to be harmful--Beta Carotene. Eat your veggies, folks and leave the pills on the shelf!

Potential 'dark side' to diets high in beta-carotene


Confirmation of what we all know, bananas, oatmeal, and oral drugs won't do it. If only they taught these teens to cut carbs!

TODAY — A Stark Glimpse of Tomorrow — NEJM

also An Editorial on the Same Study.

Read this list of unnecessary tests that you should NOT let a cardiologist perform on you. I've had some and refused another despite heavy pressure from an ER doctor. (I'd gone to the ER for something unrelated.) The last one can kill you.

From the same site's nephrology page: "Avoid nonsteroidal anti-inflammatory drugs (NSAIDS) in individuals with hypertension or heart failure or CKD of all causes, including diabetes.The use of NSAIDS, including cyclo-oxygenase type 2 (COX-2) inhibitors, for the pharmacological treatment of musculoskeletal pain can elevate blood pressure, make antihypertensive drugs less effective, cause fluid retention and worsen kidney function in these individuals. Other agents such as acetaminophen, tramadol or short-term use of narcotic analgesics may be safer than and as effective as NSAIDs."


Note that the recommendation is to get this nutrient from food, not pills. Chicken thighs will work. Bake them until crispy, paint with buffalo chicken hot sauce. Yum.Nutrient found in dark meat of poultry, some seafood, may have cardiovascular benefits

A nutrient found in the dark meat of poultry may provide protection against coronary heart disease in women with high cholesterol, according to a new study.


Experimental drug stimulates a free fatty acid receptor in the pancreas which causes insulin secretion. And weight gain. What else it does it unknown as the testing on humans was brief and in few subjects.

Medical News:New Diabetes Drug Cuts Glycemic Risk - in Endocrinology, Diabetes from MedPage Today


We recently learned Bisphenol A doubles insulin resistance, so a connection with heart disease is not that mysterious. I wish they'd correlated it with A1c. The EPIC-Norfolk study is the one that first found the tight correlation between A1c and heart disease even in the normal range.

Bisphenol A exposure linked to increased risk of future onset of heart disease


Maternal PFOA blood levels => Fat daughters 20 years later. The obesity crisis's NOT just about lifestyle choices poeple.

The levels of the environmental pollutant perfluorooctanoic acid (PFOA) that mothers had in their blood during pregnancy increased the risk of obesity in their daughters at 20 years of age.


Another reason to avoid those vegan "health food" diets. Arsenic is linked to rising rates of Type 2 diabetes. Next time you pick up an organic cereal bar or buy infant formula, you might want to read the label closely.

Arsenic found in organic baby food, cereal bars


Yet another study in which supplementing with Vitamin D does NOT improve a condition associated with low Vitamin D levels but raises blood calcium--which is dangerous to your heart. Go easy on the Vitamin D folks!

Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking.


Huge study "Surprisingly, LDL cholesterol and total cholesterol, however, were not associated with stroke risk in this population" (Older women) Triglycerides were.
Lose the carbs, baby! Carbs are what raise triglycerides.

Triglyceride levels predict stroke risk in postmenopausal women


Research, mostly rodent, showing raising insulin doesn't cause obesity unless you create hypoglycemia. Don't believe doctors who refuse insulin because "it will make you fat." Dose it right, and it won't. (I lost weight when I started insulin.)

Whole Health Source: Insulin and Obesity: Another Nail in the Coffin


MRI scan 'better' for heart patients
A magnetic resonance imaging scan for coronary heart disease is better than the most commonly-used alternative, a major UK trial of heart disease patients has shown.

MRI is better at detecting heart disease, and safer than angiogram since it doesn't involve x-rays.


An investigation by the Centers for Disease Control and Prevention, found that between 1996 and 2008, the amount of leg and foot amputations among U.S. individuals, aged 40+ with diagnosed diabetes dropped. This is good news, but there are still too many people getting amputations, mostly the very old and people in under-served poverty-striken communities who can't afford medical treatment that could lower their blood sugars.

Lower Limb Amputation Rates Associated With Diabetes Drop,


Thousands of untested new supplements have flooded the market with only the manufacturer's say-so attesting to their safety. Read this article in full if you buy pills you are told are "natural." They may contain dangerous ingredients.


Dallee said...

Thanks for posting the article on the effect of stopping smoking. I stopped about 9 months ago, gained 50 pounds immediately, lost 10 -- had my BG readings go to around 200 (my BGs had been steadily at or below 100 for the preceding 3 years, in which I followed the Bernstein low carb approach and kept my body at the 50 pounds lower weight). Now it is possible that the steriods I had been on for about a month prior to quitting smoking also played a role in throwing off my metabolism.
After juggling through different medications, metformin and Byetta keep me at around 120 fasting and post-prandial, but haven't assisted in weight loss, even though I am still adhering to a low carb diet, as I've done for almost 4 years now. (And, at the beginning of those 4 years, I dropped 50 pounds and kept it off while on metformin alone until I stopped smoking).
Looks as if low-dose insulin might be the next thing to try -- what type and what amount and what frequency, or could you share what you've done along those lines with your low-dose insulin? Thanks!

Jenny said...

Dallee, Steroids can really mess up blood sugar control and contrary to what they tell you, it can stay messed up. It was a single course of Prednisone that turned me from pre- to fully diabetic.

As far as insulin goes, what I did was to carefully read the chapters on insulin in Dr. Bernstein's book until I understood the theory of how to dose it. Insulin is very individual because we all vary so in the degree to which our fasting and post-meal insulin secretion are affected. My fasting insulin is basically normal, while the problem was with secretion at meals, so I didn't do well on basal insulin and did great with insulin that matched the carb count in my meals, but most people start out with basal insulin and that works well for them, especially with lowered carb intake.