tag:blogger.com,1999:blog-30206473.post7293979473637558032..comments2023-10-23T11:24:13.532-04:00Comments on Diabetes Update: A New MODY Gene IdentifiedJennyhttp://www.blogger.com/profile/17384082448952856117noreply@blogger.comBlogger10125tag:blogger.com,1999:blog-30206473.post-25256538427535336192009-09-08T13:42:41.580-04:002009-09-08T13:42:41.580-04:00Laura, if the metformin has such an effect that su...Laura, if the metformin has such an effect that suggests you have insulin resistance, not normally a factor in MODYs, but a familial factor in what I suffer from. I also suffer from an increase in the IR from BG spikes: if I concentrate I can feel this starting to cut in with BG around 120 and it's noticeable at 150 and upwards, too mcuh glucose in my blood but the muscles can't utilise Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-88110809541320814352009-09-01T15:13:34.942-04:002009-09-01T15:13:34.942-04:00Laura,
I'm not a doctor. So all I can do is t...Laura,<br /><br />I'm not a doctor. So all I can do is tell you that I and several other people I've heard from who have MODY do very well on low doses of fast-acting insulin at meal time. <br /><br />HOWEVER, it takes serious study to learn how to use fast acting insulin to get tight control. You will have to learn the exact carb content of every thing you eat AND weigh and measure Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-15383877998091814302009-09-01T15:02:55.927-04:002009-09-01T15:02:55.927-04:00Jenny, thanks for the info. It is so good to know...Jenny, thanks for the info. It is so good to know that I am not the only one who has had such difficulty with diagnosing and treating my diabetes. I would like to ask for your opinion on my current meds regimen. For the past 3-4 years, I have been taking Amaryl (4mg in the morning and 2 mg in the evening), metformin (2000mg) in the evening, and have recently added Byetta (5 mcg before dinner).Laurahttps://www.blogger.com/profile/11978333141772927809noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-70834630720404879572009-09-01T09:14:30.670-04:002009-09-01T09:14:30.670-04:00Hattersley & Co
http://projects.exeter.ac.uk/...Hattersley & Co<br /><br />http://projects.exeter.ac.uk/diabetesgenes/<br /><br />are pretty much the world authorities, but within a hundred miles there are some serious diabetes horror stories, so obviously their information doesn't spread far or fast.<br /><br />If you have a doctor open to this information, feed him! I suspect MODYs are rare but less so than most authorities suggest, Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-71645789716320425132009-08-31T14:44:50.798-04:002009-08-31T14:44:50.798-04:00Laura,
You'll find links of interest on this ...Laura,<br /><br />You'll find links of interest on this web page: <a href="http://www.phlaunt.com/diabetes/14047009.php" rel="nofollow">MODY</a>.<br /><br />Unfortunately, doctors have done very little study into the treatment of MODY-3, as they are more interested in finding genes that would apply to Type 2.<br /><br />The main thing is to control the post meal blood sugars. Insulin, Byetta,Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-39060274317449397512009-08-31T14:27:23.036-04:002009-08-31T14:27:23.036-04:00I would like to know where I can find more info ab...I would like to know where I can find more info about MODY 3, which I am almost certain that I have. I had my first glucose tolerance test when I was 9 years old; fasting was normal, post went up into the low 300's. Doctors repeated the test every year for the next six years, results were always the same. I was called "borderline diabetic" for the next twenty years. Had Laurahttps://www.blogger.com/profile/11978333141772927809noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-21541959305933946442009-08-16T10:03:42.003-04:002009-08-16T10:03:42.003-04:00ItsThewooo,
You really nail the problem with rare...ItsThewooo,<br /><br />You really nail the problem with rare problems. I'm so sorry you are going to lose access to the leptin. I hope some other opportunity to get it comes up.<br /><br />I don't know anything useful about the insulin oversecretion problem. Wish I could be of more help.Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-69478093084754397442009-08-16T01:48:11.458-04:002009-08-16T01:48:11.458-04:00I relate a lot to what you are going through. Via ...I relate a lot to what you are going through. Via research I've discovered leptin replacement is necessary for me to avoid numerous unpleasant side effects both acute and long term (whether due to being heterozygous for cogenital leptin deficiency or simply acquired damage to my fat tissue after massive weight loss, the fact is I make almost no leptin naturally at this point in time). <br /><ItsTheWooohttps://www.blogger.com/profile/12057537399918684119noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-75767469085888121932009-08-12T17:09:04.344-04:002009-08-12T17:09:04.344-04:00The link is fixed. Blogger was down all afternoon ...The link is fixed. Blogger was down all afternoon so it took me a while to be able to get to it.Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-68165018730208588852009-08-12T14:18:15.460-04:002009-08-12T14:18:15.460-04:00I always prick up my ears when i read about "...I always prick up my ears when i read about "new" genes being found. Everything that is wrong with me is wrong with some but not all people in one side of the family or the other. None of them seem to be monogenic though as different individuals have different subsets of symptoms - most folks on one side have some but seldom all symptoms of IR/metabolic syndrome and the diabetics are Anonymousnoreply@blogger.com