tag:blogger.com,1999:blog-30206473.post3024902704086336051..comments2023-10-23T11:24:13.532-04:00Comments on Diabetes Update: HOMA Wrong on IR and Insulin Deficiency. Early Type 2s have Insulin Deficiency NOT Just IR.Jennyhttp://www.blogger.com/profile/17384082448952856117noreply@blogger.comBlogger12125tag:blogger.com,1999:blog-30206473.post-38911418803397011642009-04-09T12:36:00.000-04:002009-04-09T12:36:00.000-04:00Anyone in glucose toxicity should be started on in...Anyone in glucose toxicity should be started on insulin, I should have been but wasn't.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-46675379593686928102009-04-08T21:59:00.000-04:002009-04-08T21:59:00.000-04:00Why not make it really simple - if a type 2 diabet...Why not make it really simple - if a type 2 diabetic is obese they have enough insulin and should NOT be given insulin secretagogues or insulin. They should work on their insulin resistance with exercise and diet.<BR/>On the other hand if a type 2 diabetic is thin they don't have enough insulin and should be started on injections.Hugh and Suzyhttps://www.blogger.com/profile/09614042460090458547noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-16067846431962777572008-08-25T14:23:00.000-04:002008-08-25T14:23:00.000-04:00Anonymous,What you describe is a common belief, bu...Anonymous,<BR/><BR/>What you describe is a common belief, but it may be incorrect.<BR/><BR/>All of the genes that have been found associated with Type 2 so far affect the ability to secrete insulin, not insulin resistance.Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-15937875733576524342008-08-25T14:17:00.000-04:002008-08-25T14:17:00.000-04:00We know that insulin is the hormone telling cells ...We know that insulin is the hormone telling cells there is food (sugar) available and that they should eat. In people heading toward diabetes, there is too much blood sugar which can lead to two problems: 1) the cells no longer respond to insulin's call to eat (this is insulin resistance) and 2) as the body is constantly trying to produce more insulin to get rid of all that sugar in the blood, atAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-77123674927473366672008-06-05T08:18:00.000-04:002008-06-05T08:18:00.000-04:00Jenny (and Scott)--Insulin resistance is a 'garbag...Jenny (and Scott)--<BR/><BR/>Insulin resistance is a 'garbage term' which has become one of the gold standard methodologies used by the American Medical Association to indicate to the patient: "We KNOW, and this is what you need to do to get well." For the diabetic patient, this includes terms like A1c, dawn phenomena, rebound, overlapping pharmacokinetics, and a host of other terms used to Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-45017531003895910062008-06-04T18:20:00.000-04:002008-06-04T18:20:00.000-04:00PJ,I'm not sure what the mechanism is, but high bl...PJ,<BR/><BR/>I'm not sure what the mechanism is, but high blood sugars do increase insulin resistance independent of the insulin level.<BR/><BR/>When I have some time, I'll look into it, but it won't be for a while.Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-14522651179405437462008-06-04T17:06:00.000-04:002008-06-04T17:06:00.000-04:00Hi Jenny! I just found your blog. This is great!Q...Hi Jenny! I just found your blog. This is great!<BR/><BR/>Question: to my understanding, high blood sugar isn't what acts on the cells of the muscles to make them insulin-resistant, that happens due to the overabundance of insulin acting on the cells. So how is the high blood sugar (NOT high insulin--insulin being 'too low') causing the IR? Just curious!PJhttps://www.blogger.com/profile/04391277875371518678noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-69983635579031185432008-06-04T15:09:00.000-04:002008-06-04T15:09:00.000-04:00This makes sense based on my own experience and gu...This makes sense based on my own experience and gut-feeling about what's going on with my own body. Thank you. Something else to discuss with my physician who fortunately has an open mind and considers her diabetic patients actually have functioning minds and know their own bodies!Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-21336490248289413482008-06-03T16:45:00.000-04:002008-06-03T16:45:00.000-04:00It's going to take several rereads to absorb the e...It's going to take several rereads to absorb the entire impact of this. Yet another Everything You Know Is Wrong moment for diabetes "common knowledge." Sigh.Russhttps://www.blogger.com/profile/15228447502575559365noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-76950914951119289302008-06-03T11:44:00.000-04:002008-06-03T11:44:00.000-04:00Scott,My guess has long been that people with Type...Scott,<BR/><BR/>My guess has long been that people with Type 1 experience what looks like IR possibly from the same reasons as some Type 2s. High blood sugars and those counterregulatory hormone surges both cause temporary IR. The counterregulatory hormones in particular, and I think people underestimate how common counterregulation may be in some of us. Certainly when Type 1s are fighting hypos Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-7888495905344261902008-06-03T11:08:00.000-04:002008-06-03T11:08:00.000-04:00This is useful, but I'd also be curious if it coul...This is useful, but I'd also be curious if it could be applied to what I like to refer to as "insulin interference" which is temporary insulin resistance usually attributed to hormone interference which causes a temporary state of insulin resistance (IR). The reason I ask is because it could also be used for a variety of reasons (applicable to both types of diabetes), and might also have Scott Shttps://www.blogger.com/profile/03286529314567223617noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-84614819070486425692008-06-03T10:42:00.000-04:002008-06-03T10:42:00.000-04:00When first diagnosed w/ type 2, I was put on oral ...When first diagnosed w/ type 2, I was put on oral meds by the doctor.But, the diabetes center nurse suggested lantus right away, which, through my ignorance, I declined. The glucovance and avandia combination was a disaster, causing water blisters on my lower legs and didn't really control my blood sugar very well. I went on lantus, byetta, and metformen, which has been a vast improvement. BTW, IBozhttps://www.blogger.com/profile/08287680290391700918noreply@blogger.com