tag:blogger.com,1999:blog-30206473.post1592414424542212546..comments2023-10-23T11:24:13.532-04:00Comments on Diabetes Update: More Research Shows Januvia and Glinides Inhibit Tumor Suppressor Gene DPP-4Jennyhttp://www.blogger.com/profile/17384082448952856117noreply@blogger.comBlogger11125tag:blogger.com,1999:blog-30206473.post-33301422526308590712012-05-10T14:28:08.071-04:002012-05-10T14:28:08.071-04:00LocalGP,
I'm pretty sure that the mechanism b...LocalGP,<br /><br />I'm pretty sure that the mechanism by which Januvia lowers blood sugar should not cause hypos because the insulin secretion should stop when blood sugar is under the threshold where 2nd phase kicks in. It may cause "false hypo" in people who are used to high blood sugars. <br /><br />The main side effects people have reported to me are severe rashes, joint Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-84483153758109344592012-05-10T14:20:38.290-04:002012-05-10T14:20:38.290-04:00Thanks Jenny for the excellent and critically impo...Thanks Jenny for the excellent and critically important inputs. I am practicing in a region (non US, non European)where this Drug (Januvia) has established itself as safe (no hypoglycemia)option in diabetes. My worry is that GPs are widely prescribing it as almost first/second option in Diabetes, and tragically even public health institutions are dispensing it freely. This is happening in an areaLocalGPhttps://www.blogger.com/profile/09241546837596478163noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-10279593232736420912009-10-19T14:37:57.120-04:002009-10-19T14:37:57.120-04:00Rat studies have failed to find cancer relationshi...Rat studies have failed to find cancer relationships with many drugs and chemicals that are linked to cancer in humans. <br /><br />The human findings in the clinical trials DID point to excess cancers--that is what Dr. Goldstein's letter in Annals of Internal Medicine pointed out. It isn't a huge number, but then the number of cases of melanoma aren't huge overall. <br /><br />Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-80269499880246632342009-10-19T12:18:34.374-04:002009-10-19T12:18:34.374-04:00I don't get it. Reviewing Merck literature the...I don't get it. Reviewing Merck literature they quote 2 year rat cancer studies and it seems reasonable. I'd welcome your comments. Here is the link to the reference:<br /><br />http://www.merck.com/product/usa/pi_circulars/j/januvia/januvia_pi.pdfUnknownhttps://www.blogger.com/profile/15378598835042148606noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-66626168379490035162009-01-02T13:15:00.000-05:002009-01-02T13:15:00.000-05:00Jenny,This is off subject, but how can I open a th...Jenny,<BR/><BR/>This is off subject, but how can I open a thread about the DOT's senseless discrimination against commercial drivers who need to take injectible insulin?<BR/><BR/>I am more than willing to discuss this discrimination at leangth with you, but please don't post my email address. It is don-ej-jones@my180.net. This address is for your use only in contacting me.<BR/><BR/>Thank you.Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-56729566674508389942008-12-24T10:03:00.000-05:002008-12-24T10:03:00.000-05:00Ween,If Januvia allows a cancer to go metastatic y...Ween,<BR/><BR/>If Januvia allows a cancer to go metastatic you won't live long enough to go blind or get amputations.<BR/><BR/>It takes at least 10 years for severe diabetes complications to develop. <BR/><BR/>Melanoma or ovarian cancer that has gone beyond stage 2 usually kills within a year. Since melanoma develops in the linings of the digestive system, not just the skin, it can be Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-85610588569182754532008-12-23T23:43:00.000-05:002008-12-23T23:43:00.000-05:00I am pretty certain that lowering my glucose to no...I am pretty certain that lowering my glucose to normal decreases my chance of developing blindness, kidney failure and amputation. Diabetes is the leading cause of these scourges. So what is wrong with the FDA using lowering of glucose or lowering of HbA1c as a "surrogate" marker of benefit. To Dr. Nissen at the cleveland clinic I say: I am blind and on dialysis (and my leg has been cut off), Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-21736205019124494682008-12-09T03:49:00.000-05:002008-12-09T03:49:00.000-05:00this medicine still need test and test....cause st...this medicine still need test and test....cause still new, some report say that the power to control blood glucose more low than suAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-30206473.post-75168896260333179272008-12-08T17:40:00.000-05:002008-12-08T17:40:00.000-05:00Nice blog! You are one of the reasons I am now on...Nice blog! You are one of the reasons I am now on Byetta and off of Januvia. Thank you for caring.The Old Man and His Doghttps://www.blogger.com/profile/09005513596375360905noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-64002030885593736262008-12-08T11:19:00.000-05:002008-12-08T11:19:00.000-05:00Scott, While the issue you raise is a step in the ...Scott, <BR/><BR/>While the issue you raise is a step in the right direction, the reason LAR wasn't approved is because of a problem already identified with Byetta--the possibility of pancreatitis. As I understand it, the problem with a longer acting drug is that it makes it impossible to cease taking the drug if pancreatitis appears.<BR/><BR/>But the problem with Januvia is different--it is that Jennyhttps://www.blogger.com/profile/17384082448952856117noreply@blogger.comtag:blogger.com,1999:blog-30206473.post-85281685282551701122008-12-08T10:58:00.000-05:002008-12-08T10:58:00.000-05:00I am hopeful (but not naive to think it is guarant...I am hopeful (but not naive to think it is guaranteed) that the FDA's use of "surrogate endpoints" as the sole criteria for approving diabetes drugs has finally come to an end. This began last year with the FDA's review of its criteria, and Steve Nissen at the Cleveland clinic was a big factor in pushing for expanded criteria.<BR/><BR/>We are already seeing this with the delay given the Amylin/Scott Shttps://www.blogger.com/profile/03286529314567223617noreply@blogger.com